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In addition, dendrimerSIN conjugates were demonstrated to selectively target activated microglia/macrophages in a rabbit model of pediatric traumatic brain injury, where they significantly attenuated acute neuroinflammation and oxidative stress compared with the free drug (150)

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Alongside these trial failures, other major challenges in developing novel IPF therapies include inadequate animal models, insufficient interventions targeting epithelial repair, and a limited understanding of how cellular senescence contributes to fibrosis (Mora et al., 2017)