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The primary endpoint was log-transformed and analysed using a normal linear model and an ANCOVA with hepatic status as factor and log body weight at baseline as covariate

Both agents upregulate -SMA and collagen, but Gepon does so without inducing endogenous TGF-1 expression or strongly engaging the SMAD-dependent signaling cascade

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nonetheless, subgroup analysis based on different diagnostic methods indicated a correlation between PPI use and SIBO when assessed using small intestine aspirate culture or the glucose hydrogen breath test but not when using the lactulose hydrogen breath test (Su et al., 2018)