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It's one of the more interesting molecules in the longevity space because it works on a metabolic pathway that training and diet alone can't fully address

47 Its prevalence has been increasing with time and is currently estimated to be around 0.01 to 0.02 per 100,000 people in the population as a whole

A key event is the blood-retinal barrier disruption, with loss of pericytes and endothelial cells, leading to microaneurysms, increased vascular permeability, and capillary obstruction, resulting in poor oxygen distribution in the retina (Wang and Lo, 2018