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15-LOX and 15-LOX-B undergo localization to biological membranes and selectively oxygenate PE-AA thereby inducing ferroptosis (Snodgrass and Brune, 2019)

4.6.6 Oxidative Stress Oxidative stress plays a key role in neuronal injury and aging by altering the structure of cellular components (lipids, proteins, DNA, and RNA), leading to mitochondrial damage, and ultimately, cell death [8, 273]