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Conclusion: PQQ can regulate the pathogenesis of myocardial hypertrophy through the induction of YAP-related anti-ferroptotic activity, highlighting the potential value of PQQ as a novel therapeutic agent capable of slowing or preventing the progression of myocardial hypertrophy and thus delaying the onset of heart failure

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MONALEESA-2 is a pivotal Phase III trial of ribociclib in combination with letro/ole, compared to lelro/ole alone in postmenopausal women who had received no prior therapy lor their HR+/HER2- advanced breast cancer

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