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As a dual GLP-1 and GIP receptor agonist, Tirzepatide affects multiple pathways simultaneously: It slows gastric emptying, enhances insulin secretion in a glucose-dependent manner, suppresses glucagon secretion, and powerfully suppresses appetite

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254 It is the second non-hormonal drug approved for the treatment of menopausal vasomotor symptoms, the other being the selective serotonin reuptake inhibitor (SSRI) paroxetine (Bridselle)