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Subsequent studies will need to clearly evaluate the safety and risk associated with more invasive measures that efficiently transduce or treat smaller areas, compared with broader, less-invasive means of distribution associated with limited brain penetrance due to the need to bypass the BBB

Glutathione helps keep the thiols of proteins and other compounds in a reduced state and is also involved in the metabolism of other antioxidants, such as vitamin C (ascorbate) and vitamin E (alpha-tocopherol) (17

Recent investigations have revealed a novel role for autophagy in cancer cell death, showing that autophagy can initiate the breakdown of ferritin, consequently triggering ferroptosis (143)

and Valado, A

Lapenna D., Glutathione and Glutathionedependent Enzymes: From Biochemistry to Gerontology and Successful Aging, Ageing Research Reviews 92 (2023): 102066