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However, different species often show significant quantitative and/or qualitative differences in drug metabolism, so following mitragynine/kratom consumption human exposure to 7-HMG may differ from that of rodents

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Secondly, mitochondria regulate redox balance, with balanced ROS production maintaining ECM integrity by modulating matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), while excessive mitochondrial reactive oxygen species (ROS) can lead to collagen fragmentation and elastin degradation [13,14,15]

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8 Ansari S, Haboubi H, Haboubi N