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This class of phytochemicals also exhibits anti-inflammatory activities via regulation of cellular activities in inflammatory cells and modulation of enzymatic activities involved in arachidonic acid metabolism (such as phospholipase A2 and COX) and arginine metabolism (such as NOS), as well as modulating the production of other proinflammatory molecules (Hussain et al

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As one may expect, ultrasound guidance of the botulinum toxin injection has been shown to improve the durability of the initial injection thus decreasing the need for subsequent injections and more definitive operative management for functional obstructive defecation [58]