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You Can Have Too Much B12 Some people worry about consuming too much B12, but the body excretes any excess through urine

Furthermore, human studies showed that exercise increased MOTS-c levels in skeletal muscle and blood circulation, indicating that MOTS-c is a mitochondrial-derived peptide induced by skeletal muscle exercise (9, 10)

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Cureus 9(8):e1577 Beulens JW et al (2015) Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin

Its copper-chelating properties and documented interaction with the extracellular matrix make it a reference compound for researchers studying metallopeptide biology and connective tissue signalling