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And then there are those with symptomatic B12 deficiency who test fine

They can interfere with vitamin B12 absorption from food by slowing the release of gastric acid into the stomach and thereby lead to vitamin B12 deficiency

NNMT is expected to be used for predicting ovarian cancer sensitivity to bevacizumab

& Salzberg, S

Thats the compensation: an alternate drain the cell can open to offset what you did by inhibiting NNMT, which is part of why nonstop inhibition doesnt necessarily keep delivering the same clean effect forever