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GSH acts as a cofactor in the system of methylglyoxal elimination, which consists of two enzymes called glyoxalases ( GSH AS MAIN REGULATOR OF CELLULAR REDOX STATUS AND REDOX SIGNAL TRANSDUCTION The glutathione redox couple GSH/GSSG has a great importance in the cells and together with other redox-active couples, including NADPH/NADP + , Trx-SH/Trx-SS regulates and maintains the appropriate cellular redox status

In a nitroglycerin-induced migraine model in rats, we have observed similar iron accumulation in serum (unpublished data)

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However, none of these studies have specifically selected children with mitochondrial dysfunction or disease to study, so it is difficult to know if individuals with ASD and mitochondrial dysfunction would benefit the most from these treatments or whether these treatments are effective for a wider group of children with ASD

Establishment of the early-life microbiome: a DOHaD perspective