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Despite some individual studies reporting small benefits, more methodologically rigorous trials failed to show meaningful effects

Via its MYST family histone lysine acetyltransferase (HAT) domain, KAT6A has been proposed to acetylate histone H3 at lysine 14 (H3K14) in HEK293T cells (Doyon et al, 2006), H3K9 in mouse embryos (Voss et al, 2009, 2012), and H3K23 in glioblastoma cells (Lv et al, 2017)