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Methylphenidate blocks norepinephrine and dopamine reuptake transporters, keeping more neurotransmitters in the synapse

In ALS, reduced astrocytic EAAT2 levels and altered microRNA regulation (e.g., increased miR-218 and decreased miR-124a) result in the accumulation of EAAT2-derived toxic species, accumulation of glutamate, and motor neuron degeneration

The peptide accelerates wound closure (96% closure by day 11 in enhanced formulations), stimulates blood vessel formation (angiogenesis), promotes nerve outgrowth, reduces scar formation through organized collagen deposition, and attracts immune cells for tissue remodeling

The prooxidant oxidative stress imbalance needs an antioxidant system able to balance it and the principal role in antioxidant defense is carried out by antioxidant enzymes, with the paramount involvement of small-molecule antioxidant compounds like GSH

In women whose menstrual cycles cease before age 45, other causes need to be considered