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Analysis of tumour samples showed an upregulation of p21 CIP1 and p27 on palbociclib treatment and a significant reduction when compared with the palbociclib + RSL3-treated mice (Fig

At this juncture it is worth highlighting that besides the immunomodulatory mediators secreted by polarized macrophages, other immune cells of our body are also associated with immunomodulatory activities toward progression of wound healing