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Their mutation is concerned with augmented R-loop formation, which results in genomic instability and is always associated with combinatorial mutation patterns [152, 161], such as the comutation of SRSF2 (P95H)IDH2 (R140Q) found in MDS and AML [138, 162, 163]

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Blocking of myosin may be impactful in Duchenne Muscular Dystrophy (DMD) research, or in research related to muscle loss due to prolonged immobility