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Souffreau J

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In normal individuals, a severe deficiency of thiamine (VitaminB1)will produce beriberi, a disease of diffuse symptoms associated with decreased activity of the 3 thiamine-dependent enzymes (pyruvate dehydrogenase, -ketoglutarate dehydrogenase, and transketolase)

However, cranial magnetic resonance imaging showed a wide range of long T1 and T2 signals in the bilateral frontotemporal parietal lobes, short T1 signals in the bilateral pallidum (Figure 2)