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K., Hogan, M

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FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma

CC 50 values measured for atpenin A5 based on MTT and CTG closely mimic the IC 50 , with 3.6 M (MTT) and 1.0 M (CTG), respectively

UK patients should understand that: Available evidence is largely from Phase 2 studies with relatively short follow-up periods Long-term cardiovascular outcome data are not yet available for either agent Phase 3 trials are ongoing, and results will inform future regulatory submissions to the MHRA UK patients interested in accessing these treatments through clinical trials may wish to consult the NIHR 'Be Part of Research' portal (bepartofresearch.nihr.ac.uk) or ClinicalTrials.gov for current recruitment opportunities