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In contrast, evidence from a Norwegian nested case-control study involving hospital nurses demonstrated statistically significant telomere shortening associated with long-term NS ( 6 consecutive nights, for 5 years)

Therapeutically, the axis can be interrupted by iron chelation (e.g., deferoxamine or deferiprone, with awareness of anemia/infection risks), radical-trapping antioxidants (ferrostatin-1, liproxstatin-1), selenium supplementation or GPX4 support (restoring the glutathioneGPX4 system), limiting LIP release by restraining ferritinophagy and, context-dependently, LOX/ACSL4 modulation or reinforcement of FSP1/CoQ10 defensesalways paired with biomarker guidance (LIP assays, ferritin/NCOA4/HO-1 status, lipid-peroxide readouts) to avoid blunting physiological iron/redox signalling (Mao et al

In vitro reactive oxygen species (ROS) assay ARPE-19 cells were cultured as above then seeded at a concentration of 2.5 10 4 cells/well (200 L) in fresh culture media in 96-well black walled, clear bottom tissue culture treated plates for fluorescence detection

The larger subcutaneous adipose tissue depots in healthy women than in healthy men provide a mechanism for lipid storage

HC, Healthy Controls