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You may begin to notice subtle changes within two to three days, with full results developing over seven to ten days

[4] Patients should stop the medication and seek prompt medical care if they experience generalized rash, hives, chest tightness, or difficulty breathing

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Intriguing findings have been described in a chemotherapyinduced peripheral neuropathy model, as according to Kim and colleagues the mechanical threshold in paclitaxelinduced neuropathic pain has shown circadian oscillations in rats, with a minimal pain tolerance observed during the inactivity phase (daytime for rats)