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However, in this field, various areas remain in which high-quality evidence is lacking, despite their clinical significance

48,49 Phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT), mitogen-activated protein kinase, and many other signaling pathways play important roles in cell proliferation and apoptosis

Cancer Med (2017) 6:168697

Bridge models to patients by aligning human-proximal systemsorganoids, microphysiological chips and point-of-care (POC) modalitieswith lab-grade validation (chromatography/spectrometry, calibrated reporters) to ensure external validity