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Each mechanism of dysfunction at the pre-synaptic, post-synaptic, and peri-synaptic level offers itself as a target for intervention to improve stabilization, junctional signaling, and synapse integrity [213], potentially even before symptomatic weakness in those with genetic susceptibilities

In vivo , we observed that TMAO increased the cholesterol content and decreased the bile acid and phospholipid contents of bile, thereby exacerbating gallstone formation in mice