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CRAM-1 is a highly disordered protein lacking defined protein motifs, and has the ability to sequester unstructured or unfolded proteins

In KCs, SIRT1 deacetylates the NF-B p65 subunit, inhibiting its transcriptional activity and reducing the expression of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6

doi: 10.1038/s41584-024-01158-w 287 JiangXStockwellBRConradM

The digested samples were lyophilized with a speedvac and resuspended in 0.1% trifluoroacetic acid (TFA) and 5% acetonitrile

However, roscovitine can also inhibit Cdk1, Cdk2, Cdk7, and Cdk9, the low selectivity for Cdk5 reduces its potential as a drug candidate targeting neurological disorders