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Cardiovascular complications, including cardiomyopathy and structural cardiac remodelling, appear to represent the most clinically significant outcomes, as comprehensively described by Iliakis and Stamou ( Hepatic toxicity and endocrine disruption further compound the systemic burden of AAS misuse

Metformin can reduce B12 absorption, and the MHRA advises checking B12 levels if symptoms suggest deficiency, with periodic monitoring in at-risk patients

Conditional knockout of HIF-1 in osteoclasts of mice (Ctsk-cre, HIF-1 flox/flox ) will result in severe condylar deformity during condylar growth, with shortened condylar length and disordered fibrocartilage arrangement

Glycine and nac supplements were well-received during clinical trials

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