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and elevated 4-HNE levels found in both cartilage and synovial fluid of surgically induced canine OA models, where direct intra-articular injection of 4-HNE could replicate the cartilage destruction phenotype, accompanied by significant upregulation of MMP13, ADAMTS5, and cyclooxygenase-2 (COX2) expression (Shi et al., 2014)

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OLGs that differentiate and myelinate later in life produce thinner myelin sheaths around axons and these neurons have been observed to be more susceptible to the damage in AD [32]

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