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For example, 200-HPTChC53 (MW 200 kDa, 53% quaternisation) and 600-HPTChC65 (MW 600 kDa, 65% quaternisation) significantly increased paracellular transport in Caco-2 cells via TJ opening, with the latter also inhibiting P-glycoprotein-mediated efflux (Kowapradit et al., 2010

6.1.2.3 Pharmacodynamic findings Further pharmacodynamic analysis evaluated brensocatibs inhibitory effects on different NSPs ( 6.1.3 ASPEN study (phase III clinical trial) 6.1.3.1 Study design and scope Based on positive results from the WILLOW study, Insmed initiated the large-scale Phase III ASPEN clinical trial to further validate brensocatibs long-term efficacy and safety ( 6.1.3.2 Primary efficacy results The ASPEN trial enrolled 1,721 patients across 35 countries to evaluate brensocatibs effectiveness in bronchiectasis management

These findings suggest a potential involvement of elevated copper levels in the pathogenesis of atherosclerosis