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Additionally, prolyl hydroxylase domain (PHD) inhibitors, such as the clinical drug Roxadustat (FG-4592), are capable of treating a variety of recalcitrant anaemiaincluding refractory anaemia, inflammatory anaemias, and chemotherapy-associated anaemiasby activating the HIF-2 axis [100]

In contrast, iron supplementation had no significant impact on lesion progression in this model, likely due to the intrinsic resistance of EMS lesions to iron overload-induced ferroptosis