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During the injection You may feel: Small pinprick Mild pressure Brief burning sensation The injection itself usually takes less than 10 seconds

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Mechanisms proposed to explain the effects of MTX in RA include antagonism of folate-dependent processes, stimulation of adenosine signaling, inhibition of methyl-donor production, generation of reactive oxygen species, downregulation of adhesion-molecule expression, modification of cytokine profiles, and downregulation of eicosanoids and matrix metalloproteinases [9]

It usually resolves on its own