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Heres the breakdown: C677T Mutation This mutation directly impairs the enzymes ability to produce methylfolate

doi: 10.3766/jaaa.14062 64 ScarinciN.TullochK.MeyerC.EkbergK.LindC

To further evaluate whether these predictive markers specifically reflect NAC resistance rather than overall tumor burden, we examined their associations with various clinicopathological parameters in the AMC validation cohort