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Idebenone has been shown to inhibit the Src homology and collagen (Shc) adaptor proteins, thereby reducing mitochondrial oxidative stress, inflammation, and subsequent hepatic fibrosis in preclinical studies

doi: 10.3389/fphar.2024.1391019 225 ChristakosSDhawanPAjibadeDBennBSFengJJoshiSS

The imbalance between M1 and M2 macrophages leads to inflammation, which is not only related to the function of the macrophages but also to the influence of macrophages on ferroptosis