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3.4 Non-natural peptides with anti-melanin synthesis activities In an experiment conducted in Italy to develop nontoxic natural tyrosinase inhibitors, reversed-phase high-performance liquid chromatography (RP-HPLC) and ultraviolet detection were used to study the inhibitory effects of various dipeptides on DOPA pigment formation

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Epithalon structure and discovery Chemical composition: Tetrapeptide (four amino acids) Sequence: Ala-Glu-Asp-Gly (AEDG) Also called Epitalon or Epithalone Synthetic version of epithalamin (pineal gland extract) Molecular weight: 390.35 g/mol Water-soluble peptide Discovery history: Discovered by Professor Vladimir Khavinson in St