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It is widely considered the most excruciating pain a human being can experience

Right now in 2025 there is still not enough high-quality human evidence to call it safe and effective by Australian medical standards

The exact cause of hyperuricemia is often linked to dietary factors

Clinical studies and experience show that some patients feel significant improvement within 714 days after injection, particularly those with constant burning or aching facial pain

When administered into the brain circulation and cerebrospinal fluid of mice, DSIP showed a significant, dose-dependent reduction in pain response in the tail-pinch and hot-plate tests