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The combination of weight loss, improved insulin sensitivity, and direct GLP-1R effects on hepatic lipid metabolism drives these improvements

of this final rule for a discussion of the impacts associated with the changes described in section III.D

In addition, since various types of cancer have different sensitivities to ferroptosis, we are temporarily unable to confirm whether the therapeutic strategy of inducing tumor cells ferroptosis in patients is universal

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While canonical ferroptosis regulation centers on cystine uptake and GPX4-mediated GSH utilization, the endogenous metabolic pathways governing ferroptosis sensitivity in liver tumors remain incompletely understood