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At Week 18, the mean relative change from baseline in LFC was -28.1% for Chiglitazar 48 mg (p = 0.004) and -39.5% for Chiglitazar 64 mg (p 60% of tested mice

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Beyond the pituitary, however, GHS-R1a is expressed in cardiac myocytes, hepatocytes, and hypothalamic neurons, and GHRP-6 engagement at these peripheral receptors underlies a set of cytoprotective effects not attributable to GH elevation alone: Mitochondrial metabolic reprogramming : proteomic analysis in rodent models documents concurrent upregulation of fatty acid -oxidation enzymes, electron transport chain complexes, anti-apoptotic BCL-2 family proteins, and antioxidant enzymes (SOD, catalase, peroxiredoxins) within 6 hours of GHRP-6 administration Anti-fibrotic and anti-inflammatory signalling : TGF-1 pathway modulation and stellate cell quiescence in hepatic models