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Most therapeutic peptides cause minimal side effects

Cell 187 , 16511665.e21 (2024)

The emerging picture is that ferroptosis is not governed by a single antioxidant axis but rather by an interconnected network of radical-trapping metabolites and enzymatic recycling systems

13 deaths, 7 received kidney after LT

86,97 Povorcitinib had a manageable safety profile in Phase II clinical trials in the 1575 mg dose group, with common side effects of mild infections (eg, nasopharyngitis) and dyslipidemia, and was administered orally with dose-dependent inhibition of the JAK1 pathway, which resulted in significant reductions in inflammatory markers over 16 weeks