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Glutathione is a powerful antioxidant produced by the body, composed of three amino acids: glutamine, cysteine, and glycine

Thus, it suggested that the radioprotective activity of DHS was due to its ability to elevate cellular GPx activity levels which probably inhibited the radiation-induced G/M arrest or mitotic death by augmenting DNA repair

This article begins with an overview of basic pathological mechanisms and offers a comprehensive overview of relevant therapeutic approaches and future development directions, aiming to facilitate the transition of the field from traditional generalized therapies to personalized precision medicine and to bridge the long-standing gap between basic research and clinical practice

Many of the studies remain preclinical or early phase trials, and challenges such as long term safety, large scale manufacturing, and regulatory approvals must be addressed