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In addition, hyperammonemia activates the general control non-derepressible 2 which inactivates the eukaryotic initiation factor 2 and impairs protein synthesis [41, 43]

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a lipid-nucleic acid particle suspension is added to 60-80% confluent plated cells having a cell density of from about 10 3 to about 10 5 cells/mL, more preferably about 2 10 4 cells/mL