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142 Additionally, inhibition of COX17 leads to elevated mitochondrial copper levels in leukemic stem cells, which results in reduced cellular levels of S-adenosylmethionine, subsequently decreasing global DNA methylation and increasing chromatin accessibility, which contributes to promoting the differentiation of acute myeloid leukemia cells while reducing stem cell-like characteristics

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That decline doesnt equal gone. Nutrients can shift from circulation into muscles, nerves, or the liver, where they remain available beyond the blood window

Retrospective application of a set of clinical diagnostic criteria for the diagnosis of multiple system atrophy

Cell Stem Cell 18 , 229242 (2016)