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European Journal of Endocrinology, 166 (5), 765-778

Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways

Proceedings of the National Academy of Sciences, 105 (15), 5768-5773

Yes, especially for people who dont absorb B12 well due to digestive issues, genetic variations (like MTHFR), or medications such as metformin or acid blockers