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Potential applications of the anti-inflammatory, antithrombotic and antioxidant health-promoting properties of curcumin: a critical review

However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig

Surprisingly, malignant cells can evade the deleterious effect of excessive iron and require high amounts of these reactive ions for their proliferation (Pfeifhofer-Obermair et al., 2018)

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Taking into account relevant ionic charges, the quantities of citrate together with the relatively minor concentrations of cations are sufficient to complex and ionically balance virtually all of Ni 2+ present in the phloem sap of P