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In azoles, resistance is commonly attributed to overexpression of efflux pumps (particularly in Candida ) and alterations in the sterol biosynthesis pathway (Lee et al., 2021)

Increases in H 2 S levels could also potentially lead to the persulfidation (sulfhydration) and activation of enzymes such as glycerol-3-phosphate dehydrogenase 1 (GPD1) or glycerol-3-phosphate dehydrogenase 2 (GPD2) that comprise the glycerol-3-phosphate shuttle (G3PS) to increase cytoplasmic NADH redox shuttling (Petrovic et al., 2025)

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systematically characterized differentially expressed proteins induced by cystine starvation and found that GPX4 was among the most downregulated proteins 11

My goal as a functional medicine doctor is to help facilitate this shift