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This unusual arrangement is subject to hydrolysis by only one known enzyme, namely -glutamyltranspeptidase (GGT), which is only present on the external surfaces of certain cell types (Meister and Anderson, 1983)

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Its discovery opened a new chapter in sleep science, establishing that the brain produces discrete peptide signals capable of modulating sleep architecture a concept that has since expanded into a broader field of sleep-regulatory neuropeptide research