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The rats were housed in an animal room with regulated temperature (2022C), 50% humidity, and a 12-h light/12-h dark cycle with free access to water and solid food

In the pivotal STEP 1 clinical trial, participants who received weekly semaglutide injections lost an average of 14.9% of their body weight over 68 weeks , compared with 2.4% in the placebo group (study in the New England Journal of Medicine )