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This contrasts with the aforementioned direct protective effects targeting the brain or spinal cord in neurological diseases, yet shares a consistent mechanistic core: upregulating Nrf2 at central nervous system sites can significantly influence the pathological progression of systemic or multi-system diseases

PMID 3678589

Then, oral eradication therapy with high-dose trimethoprimsulfamethoxazole is used to complete the treatment for a full 20 weeks [19]

There is a report in which paclitaxel appeared to induce NF-B and stabilize hypoxia-inducible factor-1alpha (HIF-1), which translated to increased production of VEGF [120]