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In recent years, various novel technologies or approaches have been incorporated to fabricate the new generation of NGCs composed of various types of biomimetic and functional scaffolds with modifications in their basic topological, biochemical, and physical properties, which not only provides physical neural support but can also rebalance the disturbed neuronal microenvironment through modulating the four key neural regeneration factors, including immune responses, intraneural vascularization, bioenergetic metabolism, and bioelectrical conduction [62, 63]