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These cells secrete various mediators that are directly responsible for the progression of allergy and bronchial obturation in asthma ( de novo synthesized prostaglandin D2 (PGD2), leukotriene C4 (LTC4), adenosine, and ROS are released from mast cell granules ( Figure 1 )

3 Once activated by infection, neutrophils are rapidly recruited to sites of inflammation in the lungs, where they produce and secrete cytokines, enzymes, including elastase (NE), reactive oxygen species (ROS) by oxidative burst, and finally release DNA to form neutrophil extracellular traps (NETs)

This aligns with the perspective that single-target interventions may disrupt metabolic network homeostasis and activate compensatory pathways 60

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However, astrocytes and microglia are profoundly altered structurally and functionally in the aged brain, and these changes extend to the cells and structures they support (Figure 2A)