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Third, although changes in the AMPK pathway were observed upon SIRT1 modulation, the direct relationship between SIRT1 and AMPK in NIHL models requires in vivo experimental confirmation

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This is in line with earlier findings that up-regulation of PR-1a is a reliable marker of the SA mediated defense pathway ( Earlier studies showed that the artificial elevation of endogenous GSH levels in virus-infected plant leaves by the application of the synthetic cysteine precursor OTC results in strongly attenuated disease symptoms and often also in decreased virus contents ( Figures 2 , 3 )

Proceedings of the National Academy of Sciences of the United States of America, 117 (3), 16211627