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It is crucial to identify the core targets that lead to pathological changes from quantitative to qualitative changes during this process, and the above preventive interventions, sleep improvement, physical exercise, dietary regulation, and social intervention, may prolong or reverse the subclinical pathological stage (Fig

Carotenoids diet: digestion, gut microbiota modulation, and inflammatory diseases

Thermo Scientific, Rockford, IL, USA)

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As outlined previously, the generation of Th1 and Th2 responses is regulated by IL-12 and IL-10 cytokines, respectively, which are modulated by the hosts intracellular MAPK signaling pathways (Dong et al., 2002