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Specifically, PGC1 increases the expression of Sirt3, which in turn deacetylates NRF1, the transcription factor responsible for TFAM transcription (94)

10.1371/journal.pone.0056306 69 LuoY.YuY.ZhangM.HeH.FanN

Yew, B., Alladi, S., Shailaja, M., Hodges, J

Sheth KR, Keays M, Grimsby GM, Granberg CF, Menon VS, DaJusta DG, Ostrov L, Hill M, Sanchez E, Kuppermann D, Harrison CB, Jacobs MA, Huang R, Burgu B, Hennes H, Schlomer BJ, Baker LA (2016) Diagnosing Testicular Torsion before Urological Consultation and Imaging: Validation of the TWIST Score