glutathione pathway metabolites One-carbon metabolism and (GSH) synthesis and metabolism Glutathione System from Cyanobacteria to

Thus, the effects of PUFA (AA and AdA) to promote cell survival or induce ferroptosis may be dose dependent (Reference Tang, Zhou and Hooi66)

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In addition, Nrf2 can influence the expression of genes encoding GSH-synthesizing proteins, such as SLC7A11, GCLC/GLCM, and GSS (Saha et al., 2023), thereby inhibiting peroxide production

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These include cumulative oxidative stress, DNA damage, overactivation of the mechanistic target of rapamycin complex 1 (mTORC1) signaling, melanocyte senescence, and reduced production of pigmentation-promoting factors in the hair matrix